AUTHOR=Schwartz Lihi , Matania Naor , Levi Matanel , Kushnir Shiri , Yosef Noga , Hoogi Assaf , Lazebnik Teddy , Shlomi Dekel 

TITLE=A blood test-based machine learning model for predicting lung cancer risk

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1577451

DOI=10.3389/fmed.2025.1577451

ISSN=2296-858X

ABSTRACT=BackgroundThe goal of early detection is individual cancer prediction. For lung cancer (LC), age and smoking history are the primary criteria for annual low-dose CT screening, leaving other populations at risk of being overlooked. Machine learning (ML) is a promising method to identify complex patterns in the data that can reveal personalized disease predictors.MethodsAn ML-based model was used on blood test data collected before the diagnosis of LC, and sociodemographic factors such as age and gender among LC patients and controls were incorporated to predict the risk for future LC diagnosis.ResultsIn addition to age and gender, we identified 22 blood tests that contributed to the model. For the entire study population, the ML model predicted LC with an accuracy of 71.2%, a sensitivity of 63%, and a positive predictive value of 67.2%. Higher accuracy was found among women than men (71.8 vs. 70.8) and among never smokers than smokers (73.6 vs. 70.1%). Age was the most significant contributor (13.6%), followed by red blood cell distribution (5.1%), creatinine (5%), gender (3.6%), and mean corpuscular hemoglobin (3.3%). A majority of the blood tests made a highly variable contribution to the complex ML model; however, some tests, such as red cell distribution width, mean corpuscular hemoglobin, prothrombin time, hematocrit, urea, and calcium, contributed slightly more to a dichotomous prediction.ConclusionBlood tests can be used in the proposed ML model to predict LC. More studies are needed in basic science fields to identify possible explanations between specific blood results and LC prediction.