AUTHOR=Liu Weiqian , Gao Bo , Xie Shaowei , Yan Dongrui , Yin Yu 

TITLE=Case Report: Anaphylactic shock induced by cefoperazone sodium and sulbactam sodium for injection

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1579601

DOI=10.3389/fmed.2025.1579601

ISSN=2296-858X

ABSTRACT=RationaleCefoperazone-sulbactam is a widely used antibiotic in clinical practice, and anaphylactic shock is a severe adverse drug reaction. Previous literature has rarely reported cases of anaphylactic shock induced by cefoperazone-sulbactam.Patient concernsA 38-year-old male patient who underwent surgery for cerebral hemorrhage developed fever, with considerations of pulmonary and urinary tract infections. Following the administration of injectable cefoperazone-sulbactam, he experienced anaphylactic shock.DiagnosisAnaphylactic shock was suspected to be caused by injectable cefoperazone-sulbactam.InterventionsThe patient was administered a subcutaneous injection of 1 mg epinephrine, followed by continuous infusion of 10 mg norepinephrine in 45 mL of 5% glucose solution via a pump. Additionally, assisted ventilation with a respirator and fluid resuscitation were provided.OutcomeThe patient was discharged with improved symptoms.LessonsTo prevent serious adverse reactions, it is essential to strictly adhere to indications and contraindications to avoid misuse and minimize the occurrence of adverse effects. Prior to medication administration, a thorough inquiry into the patient’s drug allergy history and family history should be conducted.