AUTHOR=Cheong Ezekiel Ze Ken , Wong Qiu Ying , Cajucom-Uy Howard , Htoon Hla Myint , Ang Marcus 

TITLE=Clinical outcomes in imported endothelium-in preloaded vs. surgeon-loaded DMEKs in Asian eyes

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1580733

DOI=10.3389/fmed.2025.1580733

ISSN=2296-858X

ABSTRACT=PurposeTo perform a direct, prospective, comparative analysis of the complications associated with imported preloaded grafts versus surgeon-loaded grafts in Descemet membrane endothelial keratoplasty (DMEK) in Asian eyes.MethodsA total of 20 consecutive preloaded DMEKs were matched by donor age with 40 surgeon-loaded DMEKs for the indications of Fuchs’ endothelial cell dystrophy (FECD) and pseudophakic bullous keratopathy (PBK). All cases of preloaded and surgeon-loaded DMEKs were by a single surgeon in the Singapore National Eye Centre and utilized endothelium-in pull-through cartridges (CORONET DMEK Endoglide; Network Medical Products, United Kingdom). Imported preloaded grafts were prepared 72 to 96 h before surgery. The main outcome measures were intra-operative complications such as graft tears, extrusion, and high vitreous pressure. Secondary outcome measures were endothelial cell loss and early post-operative complications such as ocular hypertension, graft detachment, and rebubbling, up to 6 months post-operatively.ResultsPreloaded DMEKs had significantly shorter intra-operative times (26.2 min vs. 39.5 min; p < 0.001) than surgeon-loaded DMEKs but were associated with increased intra-operative risk of conversion to standard injector-DMEK (15% vs. 0%; p = 0.033). However, there was no increase in overall intra-operative complications (40% vs. 22.5%; p = 0.156), early post-operative complications (35% vs. 30%; p = 0.772), and rebubbling rate (5% vs. 5%; p > 0.999). Visual outcomes and endothelial cell loss were not significantly different in both groups.ConclusionIn our Asian study cohort of pull-through DMEKs, endothelium-in preloaded DMEKs were significantly faster than surgeon-loaded DMEKs and had comparable clinical outcomes.