AUTHOR=Armadá-Maresca Felix , Capote-Díaz María , Cidad-Betegón María del Pino , Cordero-Ros Rosa María , Martínez-Godoy Lilian , Vázquez-Colomo Paola , Laín-Olia Beatriz , Songel-Sanchís Bruno , Caminos-Melguizo Alfonso , Baoud-Ould-Haddi Inas TITLE=Clinical performance of an interactive platform based on artificial intelligence in ophthalmology: experience in a third-level reference center JOURNAL=Frontiers in Medicine VOLUME=Volume 12 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1593556 DOI=10.3389/fmed.2025.1593556 ISSN=2296-858X ABSTRACT=ObjectiveTo assess the diagnostic performance of an interactive platform for ophthalmology in a real-world clinical setting at a tertiary care center.MethodsA prospective, observational, cross-sectional study was conducted on consecutive patients referred by general practitioners to the Ophthalmology Department of a third-level University Hospital. Participants underwent automated ocular evaluation using DORIA (Robotic Ophthalmological Diagnosis through Artificial Intelligence) including the Eyelib™ Robotized scan (MIKAJAKI, Geneva, Switzerland).ResultsOf 2,774 referred patients, 2,478 (89.3%) attended their appointments and were examined. Among them, the mean age was 58.5 ± 14.5 years and 1,535 (61.9%) were women. Visual acuity loss with 591 (24.2%) patients and fundus examination 421 (17.3%) patients were the most common referral reasons. Based on DORIA results, ophthalmologists concluded that 807 patients (32.6%) required no further ophthalmological care, 858 (34.6%) needed follow-up with a general ophthalmologist, and 341 (13.8%) were referred to primary care. In a detailed assessment of 2,478 cases, 1,148 (46.3%) were discharged or referred to primary care, while 472 (35.5%) individuals required specialized ophthalmology care.ConclusionThe platform might be considered as a valuable solution to the waiting list issue, reducing specialist interventions, and optimizing healthcare resources. Real-world findings suggest potential cost savings and improved patient management. Further studies are necessary to validate its comparative effectiveness.