AUTHOR=Wang Yaping , Yu Weiguang , Zhi Hui , Shang Kun , Yin Hongmei , Shan Dandan , Li Xiao , Li Wenxia , Zhang Xiuru , Zhang Baoli 

TITLE=Development and validation of a perioperative risk prediction model for pressure ulcers in neurosurgical procedures: a machine learning approach with protocol compliance metrics

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1600481

DOI=10.3389/fmed.2025.1600481

ISSN=2296-858X

ABSTRACT=BackgroundThis study aimed to develop and validate a nomogram for predicting pressure ulcer (PU) incidence in neurosurgical patients to enhance postoperative risk management.MethodsA retrospective analysis of 1,020 patients across four tertiary centers (2005–2025) evaluated 20 variables. Propensity score matching (PSM) addressed confounding, while LASSO regression and machine learning identified predictors. Model performance was assessed via AUC-ROC, C-index, and decision curve analysis.ResultsEight independent predictors of PU were identified: diabetes duration, BMI, albumin, prealbumin, age, hemoglobin, temperature difference, and urinary incontinence. The training set achieved an AUC-ROC of 0.825 (95% CI: 0.797–0.853) with 77% sensitivity and 92% specificity, while the validation set showed an AUC-ROC of 0.800 (95% CI: 0.753–0.847) with 76% sensitivity and 92% specificity. The nomogram demonstrated recalibrated C-indices of 0.833 (training) and 0.826 (validation). Decision curve analysis confirmed significant net benefit across clinical thresholds.ConclusionThis validated nomogram enables early PU risk stratification, facilitating personalized postoperative interventions. Given its high sensitivity and specificity, the model can be integrated into clinical practice to assist in early identification of high-risk patients, thereby improving patient outcomes through timely interventions.