AUTHOR=Zhang Guanyu , Li Yan , Wang Tingting , Shi Guokun , Jin Li , Gu Zongyun 

TITLE=Med-DGTN: Dynamic Graph Transformer with Adaptive Wavelet Fusion for multi-label medical image classification

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1600736

DOI=10.3389/fmed.2025.1600736

ISSN=2296-858X

ABSTRACT=IntroductionMulti-label classification of medical imaging data aims to enable simultaneous identification and diagnosis of multiple diseases, delivering comprehensive clinical decision support for complex conditions. Current methodologies demonstrate limitations in capturing disease co-occurrence patterns and preserving subtle pathological signatures. To address these challenges, we propose Med-DGTN, a dynamically integrated framework designed to advance multi-label classification performance in clinical imaging analytics.MethodsThe proposed Med-DGTN (Dynamic Graph Transformer Network with Adaptive Wavelet Fusion) introduces three key innovations: (1) A cross-modal alignment mechanism integrating convolutional visual patterns with graph-based semantic dependencies through conditionally reweighted adjacency matrices; (2) Wavelet-transform-enhanced dense blocks (WTDense) employing multi-frequency decomposition to amplify low-frequency pathological biomarkers; (3) An adaptive fusion architecture optimizing multi-scale feature hierarchies across spatial and spectral domains.ResultsValidated on two public medical imaging benchmarks, Med-DGTN demonstrates superior performance across modalities: (1) Achieving a mean average precision (mAP) of 70.65% on the retinal imaging dataset (MuReD2022), surpassing previous state-of-the-art methods by 2.68 percentage points. (2) On the chest X-ray dataset (ChestXray14), Med-DGTN achieves an average Area Under the Curve (AUC) of 0.841. It outperforms prior state-of-the-art methods in 5 of 14 disease categories.DiscussionThis investigation establishes that joint modeling of dynamic disease correlations and wavelet-optimized feature representation significantly enhances multi-label diagnostic capabilities. Med-DGTN’s architecture demonstrates clinical translatability by revealing disease interaction patterns through interpretable graph structures, potentially informing precision diagnostics in multi-morbidity scenarios.