AUTHOR=Huang Linxiang , Gao Peiliang , Fu Xueying , Wang Yuran , Zhu Jihong , Dong Guiying TITLE=Case Report: A man with septic shock developed convulsions JOURNAL=Frontiers in Medicine VOLUME=Volume 12 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1605482 DOI=10.3389/fmed.2025.1605482 ISSN=2296-858X ABSTRACT=Embolism has variable manifestations in infective endocarditis (IE) and might be misinterpreted in clinical settings. In this study, we reported the case of a 67-year-old man with erysipelas and septic shock who had developed a new onset of blurred vision and subsequently convulsions and multiple cerebral infarctions. Valve vegetations and patent foramen ovale were negative on the first echocardiography. After the neurologic symptom occurred, repeated echocardiography was performed and revealed vegetations on the mitral valve. As the patient had immunological complications, we suggested prolonged antibiotic therapy, but the patient requested an early discharge due to financial concerns. Under such circumstances, administering a long-acting penicillin G via an intramuscular injection once was an alternative therapy before discharge. For patients with bloodstream infection who develop any new onset symptoms related to arterial occlusion, infective endocarditis should be suspected, and repeated echocardiography is necessary.