AUTHOR=Sota Jurgen , Mejía-Salgado Germán , Guerriero Silvana , Ragab Gaafar , Costi Stefania , Paroli Maria Pia , Hinojosa-Azaola Andrea , Lopalco Giuseppe , Breda Luciana , Giardini Henrique Ayres Mayrink , Fonollosa Alex , Chimenti Maria Sole , Vitale Antonio , Gaggiano Carla , Aguilar-Barrera Blanca , Rodríguez-Camelo Laura Daniela , Guaracha-Basañez Guillermo Arturo , Hegazy Mohamed Tharwat , Dammacco Rosanna , Albano Valeria , Martín-Nares Eduardo , Espinosa-Lugo Santiago , Ghanema Mahmoud , Morrone Maria , La Bella Saverio , Cordeiro Rafael Alves , Carubbi Francesco , Conforti Alessandro , Ruscitti Piero , AlMaglouth Ibrahim , Talarico Rosaria , Gentileschi Stefano , Sfikakis Petros P. , Caggiano Valeria , Piga Matteo , Civino Adele , Ricci Francesca , Thabet Maissa , Govoni Marcello , Tufan Abdurrahman , Crisafulli Francesca , Sbalchiero Jessica , Al-Mayouf Sulaiman M. , Mauro Angela , Hashad Soad , Minoia Francesca , Olivieri Alma Nunzia , Tharwat Samar , Maggio Maria Cristina , Moshrif Abdelhfeez , Sebastiani Gian Domenico , Opris-Belinski Daniela , Hatemi Gülen , Direskeneli Haner , Alibaz-Öner Fatma , Fotis Lampros , Hernández-Rodríguez José , Conti Giovanni , Puttini Piercarlo Sarzi , Viapiana Ombretta , Giardina Annarita , Barone Patrizia , Babu Kalpana , Amin Rana Hussein , Kawakami-Campos Perla Ayumi , Gupta Vishali , Iagnocco Annamaria , Şahin Ali , Insalaco Antonella , González-García Andrés , Batu Ezgi Deniz , Carreño Ester , Del Giudice Emanuela , Chighizola Cecilia Beatrice , Conti Fabrizio , Balistreri Alberto , Frediani Bruno , Cantarini Luca , de-la-Torre Alejandra , Fabiani Claudia 

TITLE=Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1609613

DOI=10.3389/fmed.2025.1609613

ISSN=2296-858X

ABSTRACT=ObjectivesTo detect factors capable of predicting the development of macular edema (ME) throughout the disease course in patients affected by non-infectious uveitis (NIU).MethodsPredictive factors leading to the development of ME were analyzed through regression analysis. The functional impact of ME on best corrected visual acuity (BCVA) was also examined.ResultsA total of 1,160 NIU patients (1,857 eyes) were analyzed. ME was observed in 148 (12.76%), affecting 211 eyes. It was significantly more frequent in patients with non-anterior NIU (p < 0.0001, RR = 4.01), retinal vasculitis (p < 0.0001), and other structural complications (p = 0.0005). Gender, HLA-B*27 and/or HLA-B*51 positivity, and ethnicity did not show any significant impact on the prevalence of ME (p = 0.635, p = 0.372, p = 0.193, respectively). Four variables were associated with ME development during NIU course: the non–anterior anatomical pattern (p < 0.0001, OR = 4.01), the presence of retinal vasculitis (p = 0.028, OR = 1.68), complications other than ME (p = 0.044, OR = 1.51) and immunosuppressive treatment (p = 0.010, OR 1.69) while the diagnosis of Behçet disease-related uveitis was less likely to be associated with ME development (p = 0.24, OR 0.545). Mean ± SD BCVA was significantly lower in eyes with ME (0.82 ± 0.30) compared to eyes without ME (0.71 ± 0.33).ConclusionME can develop across all NIU types, but is more likely in cases involving the posterior segment and retinal vasculitis. Regular and focused monitoring is recommended for these high-risk patients. The study also highlights the limited predictive value of demographic and HLA-related factors, helping refine clinical risk stratification and predictive modeling in NIU.