AUTHOR=Chen Xinrong , Zheng Chuangjie , Wang Ke , Zhai Linzhu 

TITLE=Bleomycin-induced flagellate-like skin pigmentation in a 15-year-old girl: a case report and review

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1610203

DOI=10.3389/fmed.2025.1610203

ISSN=2296-858X

ABSTRACT=We present a detailed report of a case of flagellar-like skin pigmentation observed in a 15-year-old female patient diagnosed with ovarian yolk sac tumor following administration of a chemotherapy regimen containing bleomycin. After three cycles of chemotherapy, the patient exhibited characteristic painless, non-pruritic linear hyperpigmentation on her trunk and back. This case underscores the significance of paying attention to bleomycin-associated dermal toxicity, emphasizing the need for its early detection and management to alleviate the patient’s psychological and physical distress. Our research indicates that additional studies are necessary to comprehensively understand the underlying mechanisms of flagellar-like skin pigmentation and to identify effective prevention and treatment approaches.