AUTHOR=Peng Zhihao , Wang Shiheng , Jie Ke , Dai Yonghong , Wang Kunyu , Wu Jiahua , Wu Feng , Chen Jianrong 

TITLE=Dual locking plate fixation, PRP-augmented autologous bone grafting, and bioactive core construction for femoral fracture nonunion: a retrospective study of 52 cases

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1615628

DOI=10.3389/fmed.2025.1615628

ISSN=2296-858X

ABSTRACT=BackgroundFemoral nonunion remains a challenging orthopedic condition. This study evaluates a combined protocol integrating biomechanical stabilization (dual locking plate fixation) and maximal biological stimulation (PRP-augmented autologous bone grafting with bioactive core construction) to optimize bone healing.MethodsA retrospective analysis included 52 femoral nonunion patients treated at a tertiary trauma center (2020–2024). Outcomes assessed radiographic union (9-month and final follow-up), clinical union time, thigh incision healing, pain scores (VAS), lower extremity function (LEFS), and complications.ResultsCohort demographics: 35 males, 17 females; mean age 41.38 years, BMI 24.79 kg/m2. Nonunion subtypes: hypertrophic (36.5%, n = 19), atrophic (50%, n = 26), oligotrophic (13.5%, n = 7); locations: femoral shaft (63.5%, n = 33), supracondylar (36.5%, n = 19). All achieved union (mean follow-up: 19.01 months) with mean union time 6.56 ± 1.04 months. Postoperative outcomes: pain score 0.63 ± 0.97, LEFS 63.92 ± 5.92, incision healing 12.13 ± 1.36 days. The incidence rate of serious complications was 3.85% (2/52).ConclusionThe protocol demonstrated efficacy and safety, achieving rapid union (6.56 months), robust functional recovery (LEFS 63.92), and a low incidence of serious complications (3.85%). Biomechanical-biological integration represents a viable strategy for femoral nonunion management.