AUTHOR=Li Yaoting , Yu Tingting , Zhang Wei , Du Haiming , Hou Yankun , Tian Jiao , Hou Senlin , Zhang Lichao TITLE=The risk factors of bleeding after EUS-guided transmural drainage of pancreatic fluid collections: a single-center experience in China JOURNAL=Frontiers in Medicine VOLUME=Volume 12 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1626767 DOI=10.3389/fmed.2025.1626767 ISSN=2296-858X ABSTRACT=BackgroundEndoscopic ultrasonography (EUS) guided transmural drainage has become a first-line treatment for peripancreatic fluid collections (PFCs). Post-procedure bleeding may lead to severe clinical outcomes.AimThe purpose of this study was to explore the patient-related and surgery-related factors associated with post-EUS drainage bleeding.MethodsThis is an observational cohort study. A total of 181 patients who underwent EUS drainage at our center between June 2019 and May 2024 were enrolled analyzed in the study. Postoperative bleeding complications were observed, and patient and operation-related data were collected. Univariate and multifactorial logistics regression were performed for the risk factors that may affect postoperative bleeding. Determine the risk factors influencing bleeding after EUS drainage.ResultsWe achieved a 100% technical success rate. A total of 14 cases (7.7%) of bleeding occurred. All bleeding patients were successfully treated by conservative, endoscopic, interventional and other treatments. Logistic regression analysis showed that cyst size was an independent risk factor for bleeding after EUS-guided transmural drainage (P = 0.006; OR, 2.722; 95%CI, 1.327–5.587).ConclusionThe cyst size was an independent risk factor for bleeding after PFC drainage. Slowing the rate of decline in intracystic pressure may reduce the risk of bleeding.