AUTHOR=Ren Mian , Cao Luxi , Shen Quanquan , Zhu Bin , Wu Juan 

TITLE=Case Report: Membranous nephropathy associated with mantle cell lymphoma: a rare case

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1627010

DOI=10.3389/fmed.2025.1627010

ISSN=2296-858X

ABSTRACT=Mantle cell lymphoma (MCL) is a rare, aggressive non-Hodgkin lymphoma (NHL) that can affect the kidneys. In this research, we described a very rare case of secondary membranous nephropathy (MN) associated with MCL. A 67-year-old man manifested with impaired renal function and nephrotic syndrome (NS). Kidney biopsy revealed atypical MN and MCL cell infiltration. After eight rounds of modified R-CHOP therapy, which includes rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone, the patient achieved complete remission, accompanied by improved renal function and a reduction in proteinuria. This case demonstrates the precise diagnosis and treatment of the primary disease, which can lead to favorable outcomes.