AUTHOR=Zhang Lixin , Zeng Ruotong 

TITLE=Enhancing mental health diagnostics through deep learning-based image classification

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1627617

DOI=10.3389/fmed.2025.1627617

ISSN=2296-858X

ABSTRACT=IntroductionThe integration of artificial intelligence (AI) and machine learning technologies into healthcare, particularly for enhancing mental health diagnostics, represents a critical frontier in advancing patient care. Key challenges within this domain include data scarcity, model interpretability, robustness under domain shifts, and trustworthy decision-making—issues pivotal to the context of mental health and cognitive neuroscience.MethodsWe propose a novel deep learning framework, MedIntelligenceNet, enhanced with Clinical-Informed Adaptation. MedIntelligenceNet integrates multi-modal data fusion, probabilistic uncertainty quantification, hierarchical feature abstraction, and adversarial domain adaptation into a unified model architecture. The Clinical-Informed Adaptation strategy employs structured clinical priors, symbolic reasoning, and domain alignment techniques to address interpretability and robustness concerns in healthcare AI.ResultsEmpirical evaluations conducted on multi-modal mental health datasets demonstrate that our framework achieves notable improvements in diagnostic accuracy, model calibration, and resilience to domain shifts, surpassing baseline deep learning methods.DiscussionThese results underscore the effectiveness of integrating clinical knowledge with advanced AI techniques. Our approach aligns with broader goals in healthcare AI: fostering more personalized, transparent, and reliable diagnostic systems for mental health. Ultimately, it supports the development of diagnostic tools that generalize better, quantify uncertainty more reliably, and align more closely with clinical reasoning.