AUTHOR=Pugazenthi Sangami , Pari Shree S. , Zhang Ziyan , Silverstein Julie , Kim Albert H. , Patel Bhuvic 

TITLE=The evolution and application of multi-omic analysis for pituitary neuroendocrine tumors

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1629621

DOI=10.3389/fmed.2025.1629621

ISSN=2296-858X

ABSTRACT=Pituitary neuroendocrine tumors (PitNETs) are a heterogeneous group of intracranial neoplasms that vary in hormonal activity, histological features, and clinical behavior. The rise of high-throughput sequencing and molecular profiling technologies has enabled multiomic approaches—including genomics, transcriptomics, epigenomics, proteomics, and metabolomics—to deepen our understanding of PitNET pathogenesis. These studies have identified key mutations, transcriptional lineages, epigenetic modifications, and proteomic features that contribute to tumor subtype classification, invasiveness, and treatment response. Integrative multi-omic analyses have further revealed distinct molecular subtypes, complex regulatory networks, and molecular profiles that can predict recurrence and therapeutic efficacy. These approaches hold strong potential for advancing personalized medicine in PitNETs, supporting patient-specific diagnosis, prognostication, and therapeutic strategies. Future directions include the application of emerging -omic technologies and the development of robust computational tools to integrate and translate multi-layered data into clinically actionable insights.