AUTHOR=Guo Zhifeng , Huang Linghong , Chen Shaohua , Chen Yunfeng 

TITLE=Rapidly progressive relapsing polychondritis following surgery for lung adenocarcinoma: a case report

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1629991

DOI=10.3389/fmed.2025.1629991

ISSN=2296-858X

ABSTRACT=BackgroundRelapsing polychondritis (RP) is a rare autoimmune disease. This paper reports a unique case of RP with rapid progression after surgery for lung adenocarcinoma.Case presentationA 75-year-old man presented with a right upper lung mass on physical examination, which was finally diagnosed as invasive adenocarcinoma (stage IB) by pathology, and underwent thoracoscopic lobectomy without further chemotherapy or immunotherapy. Within 90 days after surgery, the patient developed shortness of breath, cough, and redness and swelling of the ear, and he was subsequently diagnosed with RP after pathological examination of the auricular cartilage. The patient experienced temporary improvement with mechanical ventilation, methylprednisolone, and intravenous immunoglobulin therapy, during which time comprehensive rehabilitation was initiated. However, he subsequently developed upper gastrointestinal bleeding, polymicrobial infections, and hemophagocytic syndrome, which proved fatal.ConclusionThis case highlights the rare temporal correlation of RP as a paraneoplastic syndrome that can occur prior to or concurrently with tumor onset, but it may also arise following tumor resection. Because of the rarity and adverse consequences of RP, clinicians should improve their recognition of the disease to permit early diagnosis and treatment.