AUTHOR=Zhang Jianguo , Gao Jian , Feng Haoyu , Liu Wei 

TITLE=A machine learning and nomogram-based study: effect of applying biologically formulated platelet-rich plasma (PRP) on the degree of pain relief after rotator cuff repair and prediction modeling, integrating biomedicine and artificial intelligence

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1647551

DOI=10.3389/fmed.2025.1647551

ISSN=2296-858X

ABSTRACT=IntroductionRotator cuff repair, a common orthopedic surgery, often leads to considerable postoperative pain that delays functional recovery. Platelet-rich plasma (PRP) has been increasingly used as a biologically active autologous therapy to promote tendon healing and reduce inflammation, but its analgesic effects remain inconsistent across individuals. Conventional linear models may fail to account for complex patient-specific interactions such as age, body mass index (BMI), and preexisting inflammatory status.MethodsWe developed a machine learning–based prediction model combined with a nomogram to assess the analgesic efficacy of PRP following rotator cuff repair. Clinical and demographic variables were incorporated to capture nonlinear relationships influencing pain reduction.ResultsThe machine learning framework demonstrated improved predictive accuracy compared with traditional models. The nomogram provided an interpretable and clinically applicable visualization of individualized pain-relief trajectories.DiscussionThis study highlights the potential of integrating machine learning and nomogram approaches to enhance personalized prediction of PRP analgesic response. Such individualized forecasting tools may support tailored postoperative management strategies and optimize rehabilitation outcomes.