AUTHOR=Balageas Anna-Chloé , Vercouillie Johnny , Arlicot Nicolas , Dupont Anne-Claire , Santiago Ribeiro Maria-Joao 

TITLE=Case Report: The Alzheimer’s paradox: a clinically stable amnestic syndrome with full biomarker positivity and minimal imaging evidence

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1653232

DOI=10.3389/fmed.2025.1653232

ISSN=2296-858X

ABSTRACT=We report the case of a 75-year-old patient with a clinically isolated and stable amnestic syndrome over fifteen years, despite a cerebrospinal fluid (CSF) profile strongly consistent with Alzheimer’s disease (AD). Serial PET imaging over two years showed only limited amyloid accumulation, no significant tau deposition, no hypometabolism, and no neuroinflammation. This case illustrates a striking dissociation between biomarker positivity and clinical progression, raising important questions about individual resilience and the prognostic value of AD biomarkers in isolation.