AUTHOR=Huang Frank Fan , Liu Jiajun , Lu Manqi , Wu Yixun , Zhen Shanshan , Cai Yihui , Liu Zhaoxue , Qiu Mingwang , Xiao Wenwu , Huang Yuxi , Liang Junquan , Li Min , Liu Zaigao 

TITLE=Neuroimaging evidence for central mechanisms of acupuncture in non-specific low back pain: a systematic review and meta-analysis

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1657241

DOI=10.3389/fmed.2025.1657241

ISSN=2296-858X

ABSTRACT=ObjectivesNon-specific low back pain (NSLBP) is a prevalent disorder with significant global health impacts. This systematic review and meta-analysis assessed acupuncture’s clinical effectiveness for NSLBP and explored its brain mechanisms using fMRI.MethodsA comprehensive search of multiple databases (PubMed, Embase, Cochrane Library, Web of Science, Science Direct, China National Knowledge Infrastructure, Wanfang Data, Chinese Technical Periodicals Database, and Chinese Biomedical Literature Database) was conducted from inception to July 11th, 2024. We included randomized controlled trials (RCTs) or non-RCTs resting-state functional magnetic resonance imaging to observe the effect of acupuncture on NSLBP. GingerALE 3.0.2 was used as the meta-analysis tool, and meta-analysis was performed in the Montreal Neurological Institute coordinate space.ResultsThe review synthesized evidence from ten studies involving 358 participants. Subgroup analyses indicated that acupuncture significantly reduced pain scores compared to sham acupuncture in both acute NSLBP (WMD = −1.04, 95% CI: −1.72 to −0.36, p = 0.003) and chronic NSLBP (WMD = −0.78, 95% CI: −1.25 to −0.31, p < 0.001). Neuroimaging analyses revealed distinct brain activation patterns: acute NSLBP showed positive activation in the right sub-lobar insula, inferior parietal lobule, medial frontal gyrus, and cingulate gyrus, while chronic NSLBP demonstrated positive activation in bilateral sub-lobar insula and negative activation in motor and prefrontal regions.ConclusionAcupuncture shows significant efficacy for NSLBP, modulating pain processing through the insula and limbic system. While these results suggest therapeutic potential for both acute and chronic NSLBP, higher-quality research is needed to validate these mechanisms.Systematic review registrationProspero registration number: CRD42022342438, URL: https://www.crd.york.ac.uk/PROSPERO/view/CRD42022342438.