AUTHOR=Xu Yongzhong , Li Yunxin , Wang Feng , Zhang Yafei , Huang Delong 

TITLE=Addressing the current challenges in the clinical application of AI-based Radiomics for cancer imaging

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1674397

DOI=10.3389/fmed.2025.1674397

ISSN=2296-858X

ABSTRACT=The integration of artificial intelligence (AI) into Radiomics has transformed cancer imaging by enabling advanced predictive modeling, improved diagnostic accuracy, and personalized treatment strategies. However, the clinical application of AI-based Radiomics faces significant challenges that hinder its widespread adoption. Intrinsic limitations, such as limited datasets, data heterogeneity, and the lack of interpretability in AI models, compromise reliability and generalizability. Practical challenges, including integration into rigid clinical workflows, infrastructural constraints, regulatory barriers, and clinician training gaps, further complicate implementation. Addressing these barriers requires coordinated efforts to establish standardized imaging protocols, foster multi-institutional collaborations, and develop centralized repositories of diverse datasets. In addition, challenges programs for healthcare professionals and regulatory reforms are essential to build trust and streamline adoption. Future research should prioritize enhancing AI interpretability, conducting longitudinal studies to assess clinical impact, and incorporating patient-centered approaches to align AI models with precision medicine objectives. By overcoming these challenges, AI-based Radiomics can advance cancer imaging, improve patient outcomes, and contribute to a new era in personalized cancer care.