AUTHOR=Moderegger Eva Lotta , Dräger Sören , Preuss Sophie L. , Vorobyev Artem , Terheyden Patrick , Kridin Khalaf , Bieber Katja , Ludwig Ralf J. , Kahle Birgit , Curman Philip 

TITLE=Increased risk of deep vein thrombosis, pulmonary embolism, and all-cause mortality in chronic venous disorder: a large-scale retrospective cohort study

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1683970

DOI=10.3389/fmed.2025.1683970

ISSN=2296-858X

ABSTRACT=BackgroundChronic venous disorder (CVD), often overlooked as a significant medical burden, has recently been linked to severe health risks, especially deep vein thrombosis (DVT), and pulmonary embolism (PE). However, large-scale data are lacking. Specifically, the impact of CVD severity on the risk of thromboembolic events and the impact of procedural interventions on these risks are unknown.MethodsA retrospective cohort study of mortality and serious adverse events was conducted using electronic health records derived from the TriNetX database. Propensity-score matching and sensitivity analyses were performed to mitigate bias.ResultsWe included 463,313 patients with CVD. An increased risk of superficial vein thrombosis [SVT; hazard ratio (HR), 19.0, 95% confidence interval (CI) 17.1–21.0, p < 0.0001], DVT (3.3, 3.2–3.6), PE (2.1, 2–2.1), and mortality (1.8, 1.8–1.8) were observed. These results persisted in two sensitivity analyses. When stratifying CVD for disease severity into chronic venous disease and -insufficiency, elevated risks of thromboembolic events and all-cause mortality were observed in both groups. Comparing CVD patients with interventions to those without, the risk of DVT (0.9, 0.8–0.9), PE (0.6, 0.5–0.6) and all-cause mortality (0.5, 0.5–0.5) decreased. Conversely, the risk of SVT increased (1.8, 1.6–2.0).DiscussionIndependently of disease severity, CVD entails an increased risk for venous thromboembolic events and all-cause mortality. In CVD patients, procedural interventions are associated with reduced risks for DVT, PE and all-cause mortality. Confirmation of these potentially clinically relevant findings necessitates prospective randomized trials.