AUTHOR=Sehrawat Anjna , Sinha Siddharth , Saxena Abhishek 

TITLE=Helicobacter pylori neutrophil-activating protein: a potential Treg modulator suppressing allergic asthma?

JOURNAL=Frontiers in Microbiology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2015.00493

DOI=10.3389/fmicb.2015.00493

ISSN=1664-302X

ABSTRACT=<p>The ultimate aim of the immune system is to eliminate pathogens without being harmful to the host. But what if eliminating the pathogen in itself is discomforting for the host? One such emerging case is of <italic>Helicobacter pylori</italic>. Modern medicine, infantile vaccination, and ultra-hygienic conditions have led to progressive disappearance of <italic>H. pylori</italic> in different parts of the world. However, the adversities caused by <italic>H. pylori’s</italic> absence are much larger than those caused by its presence. Asthma is rising as an epidemic in last few decades and several reports suggest an inverse-relationship between <italic>H. pylori’s</italic> persistence and early-life onset asthma. Regulatory T cells play an important role in both the cases. This is further supported by experiments on mouse-models. Hence, need of the hour is to discern the relationship between <italic>H. pylori</italic> and its host and eliminating its negative impacts without disturbing our indigenous microbiota. To resolve whether <italic>H. pylori</italic> is a pathogen or an amphibiont is another important side. This review explores the biological basis of <italic>H. pylori</italic>-induced priming of immune system offering resistance to childhood-onset asthma. HP-NAP–Tregs interaction has been predicted using molecular docking and dynamic simulation.</p>