AUTHOR=Popowska Magdalena , Krawczyk-Balska Agata , Ostrowski Rafał , Desvaux Mickaël
TITLE=InlL from Listeria monocytogenes Is Involved in Biofilm Formation and Adhesion to Mucin
JOURNAL=Frontiers in Microbiology
VOLUME=8
YEAR=2017
URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.00660
DOI=10.3389/fmicb.2017.00660
ISSN=1664-302X
ABSTRACT=
The bacterial etiological agent of listeriosis, Listeria monocytogenes, is an opportunistic intracellular foodborne pathogen. The infection cycle of L. monocytogenes is well-characterized and involves several key virulence factors, including internalins A and B. While 35 genes encoding internalins have been identified in L. monocytogenes, less than half of them have been characterized as yet. Focusing on lmo2026, it was shown this gene encodes a class I internalin, InlL, exhibiting domains potentially involved in adhesion. Following a functional genetic approach, InlL was demonstrated to be involved in initial bacterial adhesion as well as sessile development in L. monocytogenes. In addition, InlL enables binding to mucin of type 2, i.e., the main secreted mucin making up the mucus layer, rather than to surface-located mucin of type 1. InlL thus appears as a new molecular determinant contributing to the colonization ability of L. monocytogenes.