AUTHOR=Yang Lingyu , Liu Shuyun , Ding Jinmei , Dai Ronghua , He Chuan , Xu Ke , Honaker Christa F. , Zhang Yan , Siegel Paul , Meng He TITLE=Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity JOURNAL=Frontiers in Microbiology VOLUME=Volume 8 - 2017 YEAR=2017 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.01243 DOI=10.3389/fmicb.2017.01243 ISSN=1664-302X ABSTRACT=
To explore coevolution between the gut microbiota and the humoral immune system of the host, we used chickens as the model organism. The host populations were two lines (HAS and LAS) developed from a common founder that had undergone 40 generations of divergent selection for antibody titers to sheep red blood cells (SRBC) and two relaxed sublines (HAR and LAR). Analysis revealed that microevolution of host humoral immunity contributed to the composition of gut microbiota at the taxa level. Relaxing selection enriched some microorganisms whose functions were opposite to host immunity. Particularly, Ruminococcaceae and