AUTHOR=Sharma Divakar , Dhuriya Yogesh K. , Deo Nirmala , Bisht Deepa 

TITLE=Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis

JOURNAL=Frontiers in Microbiology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.02452

DOI=10.3389/fmicb.2017.02452

ISSN=1664-302X

ABSTRACT=<p>Emergence of drug resistant tuberculosis like multi drug resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and totally drug resistant tuberculosis (TDR-TB) has created a new challenge to fight against these bad bugs of <italic>Mycobacterium tuberculosis</italic>. Repurposing and revival of the drugs are the new trends/options to combat these worsen situations of tuberculosis in the antibiotics resistance era or in the situation of global emergency. Bactericidal and synergistic effect of repurposed/revived drugs along with the latest drugs bedaquiline and delamanid used in the treatment of MDR-TB, XDR-TB, and TDR-TB might be the choice for future promising combinatorial chemotherapy against these bad bugs.</p>