AUTHOR=Lin Fengming , Li Chengcheng , Chen Zhan 

TITLE=Bacteria-Derived Carbon Dots Inhibit Biofilm Formation of Escherichia coli without Affecting Cell Growth

JOURNAL=Frontiers in Microbiology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.00259

DOI=10.3389/fmicb.2018.00259

ISSN=1664-302X

ABSTRACT=<p>Biofilms are deleterious in many biomedical and industrial applications and prevention of their formation has been a pressing challenge. Here, carbon dots, CDs-LP that were easily synthesized from the biomass of <italic>Lactobacillus plantarum by</italic> one-step hydrothermal carbonization, were demonstrated to prevent biofilm formation of <italic>E. coli</italic>. CDs-LP did not thwart the growth of <italic>E. coli</italic>, indicating the anti-biofilm effect was not due to the bactericidal effect. Moreover, CDs-LP did not affect the growth of the animal cell AT II, showing low cytotoxicity, good safety and excellent biocompatibility. Therefore, CDs-LP could overcome the cytotoxicity issue found in many current antibiofilm agents. CDs-LP represent a new type of anti-biofilm materials, opening up a novel avenue to the development of biofilm treatment.</p>