AUTHOR=Pavia Charles S. , Plummer Maria M. TITLE=Transfusion-Associated Lyme Disease – Although Unlikely, It Is Still a Concern Worth Considering JOURNAL=Frontiers in Microbiology VOLUME=Volume 9 - 2018 YEAR=2018 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.02070 DOI=10.3389/fmicb.2018.02070 ISSN=1664-302X ABSTRACT=Hematogenous spread of the Lyme disease spirochete, Borrelia burgdorferi, has been well documented, yet there have been no reports (anecdotal or published) of transfusion-associated Lyme disease. Such a possibility would seem to exist but various factors, as discussed in this perspective, make this less likely to occur. Nonetheless, if not done already, safeguards need to be put in place at blood collection and dispensing facilities to ensure that the potential for the transfer of the Lyme disease spirochete through a blood transfusion remains a theoretical consideration rather than a real possibility.