AUTHOR=Wang Yining , Ma Lina , Stipkovits Laszlo , Szathmary Susan , Li Xuerui , Liu Yongsheng 

TITLE=The Strategy of Picornavirus Evading Host Antiviral Responses: Non-structural Proteins Suppress the Production of IFNs

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.02943

DOI=10.3389/fmicb.2018.02943

ISSN=1664-302X

ABSTRACT=Viral infections can trigger the innate immune system to produce interferons (IFNs), which play important roles in host antiviral responses. Co-evolution of viruses with their hosts has favored development of various strategies to evade the effects of IFNs, enabling viruses to survive inside host cells. One such strategy involves inhibition of IFN signaling pathways by nonstructural proteins. In this review, we provide a brief overview of host signaling pathways inducing IFN production and their suppression by picornavirus nonstructural proteins. Using this strategy, picornaviruses can evade the host immune response and replicate inside host cells.