AUTHOR=Qiao Zhenyi , Han Jin , Feng Huafeng , Zheng Huajun , Wu Jiang , Gao Caixia , Yang Meng , You Chunping , Liu Zhenmin , Wu Zhengjun 

TITLE=Fermentation Products of Paenibacillus bovis sp. nov. BD3526 Alleviates the Symptoms of Type 2 Diabetes Mellitus in GK Rats

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 9 - 2018

YEAR=2019

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.03292

DOI=10.3389/fmicb.2018.03292

ISSN=1664-302X

ABSTRACT=Gut microbiota is closely related to type 2 diabetes mellitus (T2DM). The gut microbiota of patients with T2DM is significantly differed from that of healthy subjects in terms of bacterial composition and diversity. Here, we used the metabolites of Paenibacillus bovis sp. nov. BD3526 to study the disease progression of T2DM (Goto-kakisaki, GK) rats. We found that the symptoms in GK rats fed the metabolites of BD3526 were significantly improved. 16S rRNA sequencing showed that the metabolites of BD3526 had strong effects on the gut microbiota by increasing the content of Akmenmansia. In addition, the interaction of genus in the gut of BD3526 group also changed significantly. Further cytokine detection revealed that the metabolites of BD3526 can reduce the inflammatory factors in the intestinal mucus of GK rats, thereby inhibiting the inflammatory response and ameliorate the symptoms of T2DM.