AUTHOR=Santos Igor de Andrade , Grosche Victória Riquena , Bergamini Fernando Rodrigues Goulart , Sabino-Silva Robinson , Jardim Ana Carolina Gomes 

TITLE=Antivirals Against Coronaviruses: Candidate Drugs for SARS-CoV-2 Treatment?

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.01818

DOI=10.3389/fmicb.2020.01818

ISSN=1664-302X

ABSTRACT=Coronaviruses (CoVs) is a group of viruses from family Coronaviridae which can infect human and animals, causing mild to severe diseases. The ongoing pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a global threat, urging into the development of new therapeutic strategies. Here we presented a selection of relevant compounds, from 2005 up to now, with in vitro and/or in vivo antiviral activities against human and/or animal CoVs. We also presented compounds that have reached clinical trials, as well as further discuss the potentiality of other molecules towards their application in (re)emergent CoVs outbreaks. Finally, through the rationalization of the data herein presented, we wish to encourage further research encompassing these compounds as potential SARS-CoV-2 drug candidates.