AUTHOR=Liu Sha-Sha , Yang Li , Kong Fan-Dong , Zhao Jia-Hui , Yao Li , Yuchi Zhi-Guang , Ma Qing-Yun , Xie Qing-Yi , Zhou Li-Man , Guo Meng-Fei , Dai Hao-Fu , Zhao You-Xing , Luo Du-Qiang 

TITLE=Three New Quinazoline-Containing Indole Alkaloids From the Marine-Derived Fungus Aspergillus sp. HNMF114

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.680879

DOI=10.3389/fmicb.2021.680879

ISSN=1664-302X

ABSTRACT=By feeding tryptophan to the marine-derived fungus Aspergillus sp. HNMF114 from the bivalve mollusk Sanguinolaria chinensis, three new quinazoline-containing indole alkaloids named aspertoryadins H-J (1-3), along with 16 known ones (4-19), were obtained. The structures of the new compounds were elucidated by the analysis of spectroscopic data combined with quantum chemical calculations of NMR chemical shifts and ECD spectra. Structurally, compound 3 represent the first example of this type of compounds bearing an amide group at C-3. Compounds 10 and 16 showed potent α-glycosidase inhibitory activity with IC50 values of 7.18 and 5.29 μM, and compounds 13 and 14 showed clear activation effect against ryanodine receptor from Spodoptera frugiperda (sfRyR), which reduced the [Ca2+]ER by 37.1% and 36.2%, respectively.