AUTHOR=Ma Yihui , Yang Jun , Yang Dangwei , Qin Guangyu , Zu Junhuai 

TITLE=Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.728173

DOI=10.3389/fmicb.2021.728173

ISSN=1664-302X

ABSTRACT=<p>Stem rot disease caused by <italic>Sclerotium rolfsii</italic> is one of the destructive diseases in peanut and poses a big risk to peanut production. Current fungicides in the market have not provided satisfactory control efficacy and thus called for novel fungicides with different structures as an alternative treatment strategy. Our previously developed phenylpyrazole compound <bold>3c</bold> demonstrated modest inhibitory effect against <italic>S. rolfsii.</italic> The following structure modification identified an unreported compound <bold>6,</bold> which bears a 3-chloropyridinyl moiety as the most prominent derivative with an IC<sub>50</sub> of 12 μg/ml in potato dextrose agar (PDA) assay, higher than those of 0.8 and 1.8 μg/ml associated with thifluzamide and tebuconazole, respectively. However, compound <bold>6</bold> showed similar controlling effects to those of thifluzamide and tebuconazole in field study. This study underscores the potential of 1,5-diaryl-pyrazole-3-formate as an antifungal candidate for stem rot disease management.</p>