AUTHOR=Kumar Vikash , Roy Suvra , Behera Bijay Kumar , Swain Himanshu Sekhar , Das Basanta Kumar TITLE=Biofloc Microbiome With Bioremediation and Health Benefits JOURNAL=Frontiers in Microbiology VOLUME=Volume 12 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.741164 DOI=10.3389/fmicb.2021.741164 ISSN=1664-302X ABSTRACT=Biofloc system has recently attracted great attention as a cost-effective, sustainable and environmentally friendly technology and expected to contribute towards human food security (Zero Hunger SDG 2). It is also expected that this endeavour can be adopted widely because of its characteristics zero water exchange and reduced artificial feeding features. In biofloc system, the flocs which are generally formed by aggregation of heterotrophic microorganisms, serve as natural bioremediation candidates. These microbes effectively maintain water quality by utilizing the nutrient wastes, mostly originated from digested, unconsumed and metabolic processes of feed. Additionally, the flocs are important source of nutrients, mainly a protein source, and when these are consumed by aquaculture animals it improves the growth performance, immunity and disease tolerance of host against pathogenic microbial infection. Here in this review, we focus on recent advances that could provide a mechanistic insight on how the microbial community developed in the biofloc system helps in the bioremediation process and enhances the overall health of host. We have also tried to address the possible role of these microbial communities against growth and virulence of pathogenic microbes.