AUTHOR=Han Jicheng , Zhu Xiangyu , Gao Zihan , Xiao Yan , Zhang Jinxin , Wang Peng , Fang Jinbo , Li Yiquan , Zhu Yilong , Li Yue , Jin Ningyi , Lu Huijun , Lin Dazhuan , Liu Wenshen 

TITLE=Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 13 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1067725

DOI=10.3389/fmicb.2022.1067725

ISSN=1664-302X

ABSTRACT=Influenza viruses pose a serious threat to human health, infecting hundreds of millions of people worldwide each year, resulting in a significant increase in global morbidity and mortality. Influenza activity declined at the onset of the COVID-19 pandemic, but the genetic diversity of B/Victoria lineage viruses has increased significantly during this period. Therefore, the prevention and treatment of the influenza B Victoria strain virus should still attract extensive attention. In this study, we found that Atractylodes A (AA), one of the effective components in Atractylodes lancea (Thunb.) DC, shows a potential anti-viral infection function. This study shows that AA not only has anti-influenza B virus infection effects in vivo and in vitro, but also can regulate macrophage polarization to the M2 type, which can effectively attenuate the damage caused by influenza B virus infection. Therefore, Atractylodes A may be an effective natural drug against B/Victoria influenza infection.