AUTHOR=Zhuang Chunlan , Liu Xiaohui , Chen Qi , Sun Yuxin , Su Yingying , Huang Shoujie , Wu Ting , Xia Ningshao 

TITLE=Protection Duration of COVID-19 Vaccines: Waning Effectiveness and Future Perspective

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.828806

DOI=10.3389/fmicb.2022.828806

ISSN=1664-302X

ABSTRACT=The COVID-19 vaccines have very successfully decreased the disease risk as we know, some key information remains unknown due to the short development history and the lack of long-term follow-up studies in vaccinated populations. One of the unanswered issues is the protection duration conferred after COVID-19 vaccination, which appears to play a pivotal role in the future impact of pathogens and is critical to inform the public health response and policy decisions. Here, we review current information on long term effectiveness of different COVID-19 vaccines, persistence of immunogenicity, and gaps in knowledge. Meanwhile, we also discuss the influencing factors and future study prospects on this topic.