AUTHOR=Wei Pan-Pan , Ai Hong-Lian , Shi Bao-Bao , Ye Ke , Lv Xiao , Pan Xiao-Yan , Ma Xu-Jun , Xiao Dan , Li Zheng-Hui , Lei Xin-Xiang 

TITLE=Paecilins F–P, new dimeric chromanones isolated from the endophytic fungus Xylaria curta E10, and structural revision of paecilin A

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.922444

DOI=10.3389/fmicb.2022.922444

ISSN=1664-302X

ABSTRACT=Eleven new dimeric chromanones, paecilins F-P (2–12), were isolated from the endophytic fungus Xylaria curta E10, along with four known analogs (1, 13–15). Their structures and absolute configurations were determined by extensive experimental spectroscopic methods, single-crystal X-ray diffraction, and ECD calculations. In addition, the structure of paecilin A, which was reported to be a symmetric C8-C8 dimeric pattern, was revised by analysis of the NMR data, and single-crystal X-ray diffraction. Compound 1 showed antifungal activity against the human pathogenic fungus Candida albicans with a minimum inhibitory concentration of 16 μg/mL, and Compounds 8 and 10 showed antibacterial activity against the gram-negative bacterium Escherichia coli with the same minimum inhibitory concentration of 16 μg/mL.