AUTHOR=Dutta Pranab , Kumari Arti , Mahanta Madhusmita , Biswas K. K. , Dudkiewicz Agnieszka , Thakuria D. , Abdelrhim Abdelrazek S. , Singh S. Basanta , Muthukrishnan Gomathy , Sabarinathan K. G. , Mandal Mihir K. , Mazumdar N. TITLE=Advances in Nanotechnology as a Potential Alternative for Plant Viral Disease Management JOURNAL=Frontiers in Microbiology VOLUME=Volume 13 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.935193 DOI=10.3389/fmicb.2022.935193 ISSN=1664-302X ABSTRACT=Plant viruses cause enormous losses in agricultural production accounting of about 47% of total overall crop losses caused by plant pathogens. More than 50% of emerging plant diseases are reported to be caused by viruses, which are inevitable or unmanageable. Therefore, it is essential to devise ennoble and effective management strategies to combat the losses caused by the plant virus in economically important crops. Nanotechnology presents a new tendency against the increasing challenges in the diagnosis and management of plant viruses as well as plant health. The application of nanotechnology in plant virology, known as nanophytovirology, includes disease diagnostics, drug delivery, genetic transformation, therapeutic, plant defense induction, and bio-stimulation; however, it is still in the toddler stage. The unique physico-chemical properties of particles in the nanoscale allow greater interaction and it may knock out virus particles. Thus it opens up a noble arena for the management of plant viral diseases. The main objective of this review is to focus on the mounting collection of tools and techniques involved in viral disease diagnosis and management and to elucidate its mode of action along with toxicological concerns.