AUTHOR=Fan Yaqin , Jiang Chunjiao , Zhang Yan , Ma Zhiheng , Li Peihai , Guo Lizhong , Feng Ting , Zhou Liman , Xu Lili 

TITLE=Pro-angiogenic New Chloro-Azaphilone Derivatives From the Hadal Trench-Derived Fungus Chaetomium globosum YP-106

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.943452

DOI=10.3389/fmicb.2022.943452

ISSN=1664-302X

ABSTRACT=<p>Five new chloro-azaphilones, chaetofanixins A–E (1–5), and five known analogs (6–10) were isolated and identified from the hadal trench-derived fungus <italic>Chaetomium globosum</italic> YP-106. The structure of chaetofanixin E (5) is unique and interesting, bearing a highly rigid 6/6/5/3/5 penta-cyclic ring system, which is first encountered in natural products. The structures of these compounds, including absolute configurations, were determined based on the spectroscopic analysis, electronic circular dichroism (ECD) calculations, and analysis of biogenetic origins. Compounds 1–7 significantly promoted angiogenesis in a dose-dependent manner, and thus, these compounds might be used as promising molecules for the development of natural cardiovascular disease agents.</p>