AUTHOR=Cebrián Rubén , Martínez-García Marta , Fernández Matilde , García Federico , Martínez-Bueno Manuel , Valdivia Eva , Kuipers Oscar P. , Montalbán-López Manuel , Maqueda Mercedes TITLE=Advances in the preclinical characterization of the antimicrobial peptide AS-48 JOURNAL=Frontiers in Microbiology VOLUME=Volume 14 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1110360 DOI=10.3389/fmicb.2023.1110360 ISSN=1664-302X ABSTRACT=
Antimicrobial resistance is a natural and inevitable phenomenon that constitutes a severe threat to global public health and economy. Innovative products, active against new targets and with no cross- or co-resistance with existing antibiotic classes, novel mechanisms of action, or multiple therapeutic targets are urgently required. For these reasons, antimicrobial peptides such as bacteriocins constitute a promising class of new antimicrobial drugs under investigation for clinical development. Here, we review the potential therapeutic use of AS-48, a head-to-tail cyclized cationic bacteriocin produced by