AUTHOR=Wang Weiwei , Shi Jun , Zhang Yan , Qiao Yuanzheng , Zuo Wenbo , Wang Zhiyuan , Nong Tingbin , Hu Shichen , Chen Yang , Kong Ruiyang , He Xiumiao , Wei Ping 

TITLE=Genetic and pathogenic characterizations of a naturally occurring reassortant and homologous recombinant strain of the classical infectious bursal disease virus re-emerging in chickens in southern China

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1293072

DOI=10.3389/fmicb.2023.1293072

ISSN=1664-302X

ABSTRACT=Highlights 1. A naturally occurring reassortant and recombinant classical strain GXYL211225 (genotype A1aB1a) was isolated and characterized for the first time. 2. Segment A of GXYL211225 is a result of recombination between the classical strains 150127-0.2 (major parent) and Faragher52-70 (minor parent), and with segment B reasserting with the attenuated vaccine strain. 3. GXYL211225 exhibits an extensive cell-tropism and has been confirmed to be a naturally occurring cell-adapted strain. 4. The virulence of GXYL211225 was intermediate between that of the vvIBDV NN1172 and nvIBDV QZ191002, causing a 10% mortality rate and severe immune organ damages in chickens.