AUTHOR=Hu Xutao , Binxu Qiu , Shao Guang-zhao , Huang Yu , Qiu Wei 

TITLE=Gut microbiota, circulating metabolites, and gallstone disease: a Mendelian randomization study

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1336673

DOI=10.3389/fmicb.2024.1336673

ISSN=1664-302X

ABSTRACT=The link between Gut microbiota (GM) and Gallstone disease (GSD) is well established, but it is not clear whether there is a causal relationship between the two associations.We conducted bidirectional Mendelian randomization (MR) analyses, leveraging aggregated data from the Genome-Wide Association Study (GWAS) of GM and Circulating Metabolites. Our primary objective was to investigate the causal interplay between intestinal flora and GSD.Additionally, we performed mediational analyses, two-step MR, and multivariate MR to uncover the potential mediating effect of circulating metabolites in this relationship.Our study has revealed a causal relationship between GSD and six distinct bacterial groups.genetically predicted Class Bacilli (Odds Ratio (OR): 0.901, 95% Confidence Interval (95% CI):