AUTHOR=Xiong Yajun , Zhang Xiaonan , Niu Xiaoya , Zhang Long , Sheng Yanbing , Xu Aiguo 

TITLE=Causal relationship between gut microbiota and gynecological tumor: a two-sample Mendelian randomization study

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1417904

DOI=10.3389/fmicb.2024.1417904

ISSN=1664-302X

ABSTRACT=The causality between gut microbiota and gynecologic tumors remains unclear. This study employs Mendelian randomization (MR) to identify specific pathogenic bacterial communities associated with gynecologic tumors. We used data from the MiBioGen consortium on gut microbiota as the exposure. Uterine fibroids (UF), endometrial cancer (EC), ovarian cancer (OC), and cervical cancer (CC) were selected as outcomes. We investigated the causal relationship between gut microbiota and gynecologic tumors, conducted sensitivity analyses, and validated our findings in an independent cohort. Additionally, reverse MR explored the potential for reverse causation. We found a reduced risk of UF associated with higher Lachnospiraceae (OR: 0.882, 95% CI: 0.793-0.999, P = 0.982). Conversely, increased Lachnospiraceae was linked to a higher incidence of OC (OR: 1.329, 95% CI: 1.019-1.732, P= 0.036). This study established a causal connection between Lachnospiraceae and both UF and OC, providing new insights into the role of gut microbiota in gynecological tumors.