AUTHOR=Tang Nan , Xu Xiaoqing , Guo Zhenyu , Meng Xiangyu , Qian Guoqiang , Li He 

TITLE=Preparation of safflower fermentation solution and study on its biological activity

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1472992

DOI=10.3389/fmicb.2024.1472992

ISSN=1664-302X

ABSTRACT=In this study, a fermentation solution of safflower was developed by using microbial fermentation technology. The optimal fermentation conditions were determined by single factor test and response surface method. Then the antioxidant and anti-inflammatory effects of safflower fermentation liquid were verified by cell and zebrafish models. Finally, the safety of safflower fermentation liquid was evaluated by eye irritation test of cosmetics. Results The flavonoid of safflower was increased after fermentation, which had anti-inflammatory and antioxidant properties.