AUTHOR=Freitas Jessica Alves , Nehmi Filho Victor , Santamarina Aline Boveto , Murata Gilson Masahiro , Franco Lucas Augusto Moyses , Fonseca Joyce Vanessa , Martins Roberta Cristina , Souza Gabriele Alves , Benicio Gabriela , Sabbag Isabella Mirandez , de Souza Esther Alves , Otoch José Pinhata , Pessoa Ana Flávia Marçal 

TITLE=Nutraceutical supplement slim reshaped colon histomorphology and reduces Mucispirillum schaedleri in obese mice

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1494994

DOI=10.3389/fmicb.2025.1494994

ISSN=1664-302X

ABSTRACT=IntroductionBioactive compounds and whole foods have emerged as promising interventions to address gut microbiota dysbiosis linked to obesity. Compounds such as berberine and coenzyme Q10 are well-recognized for their roles in managing metabolic syndrome and exerting antioxidant effects, while beet pulp, rich in fiber and antioxidants, enhances gut health through additional prebiotic benefits.MethodsThis study evaluated the effects of a nutraceutical supplement, Slim, on the modulation of gut microbiota in obese mice induced by a high-fat diet.ResultsOur results demonstrated that Slim supplementation significantly improved lipid metabolism, reshaped colon histomorphology, and decreased levels of Mucispirillum schaedleri, which were correlated with VLDL-c and triglycerides.DiscussionWe suggest these effects are driven by a duplibiotic effect, resulting from the synergistic action of the bioactive compounds.