AUTHOR=Chachar Zaid , Xue Xiaoming , Fang Junteng , Chen Ming , Jiarui Chen , Chen Weiwei , Ahmed Nazir , Chachar Sadaruddin , Narejo Mehar-un-Nisa , Ahmed Naseer , Fan Lina , Lai Ruiqiang , Qi Yongwen 

TITLE=Key mechanisms of plant-Ralstonia solanacearum interaction in bacterial wilt pathogenesis

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1521422

DOI=10.3389/fmicb.2025.1521422

ISSN=1664-302X

ABSTRACT=Ralstonia solanacearum, a Gram-negative bacterium, is the causative agent of bacterial wilt, a devastating disease affecting a wide range of economically important crops worldwide. This study explores the dynamic interactions between Ralstonia solanacearum and its host plants, emphasizing key mechanisms underlying infection and host response. The pathogen initiates infection through root wounds or natural openings, rapidly colonizing xylem vessels where it forms biofilms that disrupt water and nutrient transport. Its virulence is driven by cell wall-degrading enzymes and effector proteins delivered via a Type III secretion system, which subvert plant immune responses and facilitate systemic spread. In turn, host plants activate hormonal and stress-related defense pathways, though these are often manipulated by the pathogen, leading to disease progression and reduced productivity. This review highlights critical gaps in our understanding of molecular host-pathogen interactions and the role of environmental conditions in disease development. Addressing these gaps is vital for improving management strategies, with breeding for resistance and advanced biotechnological tools offering promising solutions to combat bacterial wilt and support sustainable agriculture. Future research should focus on leveraging genetic insights to enhance host resistance, employing advanced biotechnological tools to develop crop varieties with enhanced resistance to Ralstonia solanacearum, thereby promoting sustainable agriculture and strengthening global food security.