AUTHOR=Wang Qingjing , Yu Haojie , Pan Xueer , Huang Weichang , Lalsiamthara Jonathan , Ullah Saif , Xu Yongchang , Lu Anwei 

TITLE=Exploring current hypervirulent Klebsiella pneumoniae infections: insights into pathogenesis, drug resistance, and vaccine prospects

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1604763

DOI=10.3389/fmicb.2025.1604763

ISSN=1664-302X

ABSTRACT=Klebsiella pneumoniae is a significant pathogenic bacterium responsible for a range of infections. The escalating prominence of K. pneumoniae in hospital-acquired infections is a deeply alarming trend that demands immediate attention and rigorous intervention. This article provides an up-to-date review of K. pneumoniae’s virulence factors, pathogenesis, and the mechanism driving drug resistance. It also explores the potential for safe and effective vaccine developments, vital for preventing and controlling these diseases. Furthermore, we summarize the epidemiological characteristics of classical and hypervirulent K. pneumoniae infections, providing an overview of drug-resistance K. pneumoniae emergence, transmission, and prevalence.