AUTHOR=Yu Yu , Li Jing , Liu Qingqing , Zhai Rongrong , Dai Yuzhu , Sun Lei 

TITLE=Advances in research on severe fever with thrombocytopenia syndrome virus

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1622394

DOI=10.3389/fmicb.2025.1622394

ISSN=1664-302X

ABSTRACT=Severe fever with thrombocytopenia syndrome (SFTS) is an acute infectious disease caused by the SFTS virus (SFTSV). Since the first reported case, SFTSV has spread globally, particularly in Asian regions such as China, South Korea, and Japan, with an increasing number of cases and a high mortality rate among severe patients. SFTSV is an RNA virus capable of rapid biological evolution through genetic mutations, reassortment, and homologous recombination. The disease primarily occurs in mountainous, forested, and hilly areas. Due to limited clinical research, the clinical characteristics and pathogenesis of SFTS remain incompletely understood. This review summarizes recent advances in the regional epidemiological characteristics, clinical features, genotyping, pathogenesis, and rapid detection methods of SFTSV.