AUTHOR=Kisilevsky Robert , Raimondi Sara , Bellotti Vittorio 

TITLE=Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=Volume 3 - 2016

YEAR=2016

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2016.00017

DOI=10.3389/fmolb.2016.00017

ISSN=2296-889X

ABSTRACT=<p>Historical and current concepts of <italic>in vitro</italic> fibrillogenesis are considered in the light of disorders in which amyloid is deposited at anatomic sites remote from the site of synthesis of the corresponding precursor protein. These clinical conditions set constraints on the interpretation of information derived from <italic>in vitro</italic> fibrillogenesis studies. They suggest that in addition to kinetic and thermodynamic factors identified <italic>in vitro</italic>, fibrillogenesis <italic>in vivo</italic> is determined by site specific factors most of which have yet to be identified.</p>