AUTHOR=Sharifi-Rad Javad , Quispe Cristina , Mukazhanova Zhazira , Knut Ewa , Turgumbayeva Aknur , Kipchakbayeva Aliya , Seitimova Gulnaz , Mahomoodally Mohamad Fawzi , Lobine Devina , Koay Aaron , Wang Jinfan , Sheridan Helen , Leyva-Gómez Gerardo , Prado-Audelo María L. Del , Cortes Hernán , Rescigno Antonio , Zucca Paolo , Sytar Oksana , Imran Muhammad , Rodrigues Célia F. , Cruz-Martins Natália , Ekiert Halina , Kumar Manoj , Abdull Razis Ahmad Faizal , Sunusi Usman , Kamal Ramla Muhammad , Szopa Agnieszka 

TITLE=Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.649395

DOI=10.3389/fmolb.2021.649395

ISSN=2296-889X

ABSTRACT=Resveratrol is a polyphenolic stilbene derivative present mainly in grapes, and red wine. It is widely known for its antioxidant properties but numerous studies have also indicated anti-inflammatory, and anti-aging abilities and, above that, a great potential in cancer therapy. Regrettably, oral administration of resveratrol has met pharmacokinetic and physicochemical limitations hampering its effects, demanding another method of administration, to ensure its efficiency. The present review explores published data concerning application of resveratrol nano-formulations in cancer therapy, with the use of different types of nano-delivery systems. Mechanisms of action with potential use in cancer therapy, negative effects, and the influence of resveratrol nano-formulations on different types of cancer is taken into account. Finally, potential toxicity of nano-resveratrol is also discussed.