AUTHOR=Jimeno Sonia , Balestra Fernando R. , Huertas Pablo TITLE=The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair JOURNAL=Frontiers in Molecular Biosciences VOLUME=Volume 8 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.664872 DOI=10.3389/fmolb.2021.664872 ISSN=2296-889X ABSTRACT=

The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated affair, in which several pathways compete for the DNA ends in a complex balance. Thus, the fine-tuning of the DNA double-strand break repair pathway choice relies on the different regulatory layers that respond to environmental cues. Among those different tiers of regulation, RNA modifications have just emerged as a promising field.