Front. Mol. Biosci. Frontiers in Molecular Biosciences Front. Mol. Biosci. 2296-889X Frontiers Media S.A. 705683 10.3389/fmolb.2021.705683 Molecular Biosciences Correction Corrigendum: Identification of a Potential miRNA-mRNA Regulatory Network Associated With the Prognosis of HBV-ACLF Ma et al. Corrigendum: A miRNA–mRNA Network of HBV-ACLF Ma Shanshan 1 2 3 † Xie Zhongyang 1 2 3 † Zhang Lingjian 1 2 3 Yang Ya 1 2 3 Jiang He 1 2 3 Ouyang Xiaoxi 1 2 3 Zhao Yalei 1 2 3 Liu Qiuhong 1 2 3 Xu Xiaowei 3 4 * Li Lanjuan 1 2 3 * State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

Edited and reviewed by: Teng Ma, Capital Medical University, China

 *Correspondence: Xiaowei Xu, xxw69@126.com; Lanjuan Li, ljli@zju.edu.cn

These authors have contributed equally to this work

This article was submitted to Protein and RNA Networks, a section of the journal Frontiers in Molecular Biosciences

 29 06 2021 2021 8 705683 06 05 2021 16 06 2021 Copyright © 2021 Ma, Xie, Zhang, Yang, Jiang, Ouyang, Zhao, Liu, Xu and Li. 2021 Ma, Xie, Zhang, Yang, Jiang, Ouyang, Zhao, Liu, Xu and Li

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 A Corrigendum on Identification of a Potential miRNA–mRNA Regulatory Network Associated With the Prognosis of HBV-ACLF by Ma, S., Xie, Z., Zhang, L., Yang, Y., Jiang, H., Ouyang, X., et al. (2021). Front. Mol. Biosci. 8:657631. doi: 10.3389/fmolb.2021.657631 hepatitis B virus acute-on-chronic liver failure prognosis network miRNA

In the original article, there was an error in the Abstract. The second paragraph titled “Methods” in the Abstract is redundant and should have been removed. A correction has been made to the Abstract:

“Background: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a life-threatening disease with a high mortality rate; the systemic inflammatory response plays a vital role in disease progression. We aimed to determine if a miRNA–mRNA co-regulatory network exists in the peripheral blood mononuclear cells (PBMCs) of HBV-ACLF patients, which might be important for prognosis.

Methods: Transcriptome-wide microRNA (miRNA) and mRNA microarrays were used to define the miRNA and mRNA expression profiles of the PBMCs of HBV-ACLF patients in a discovery cohort. The targets of the miRNAs were predicted. We built a miRNA-mRNA regulatory network through bioinformatics analysis, and used quantitative real-time polymerase chain reaction (qRT-PCR) to assess the importance of candidate miRNAs and mRNAs. We also assessed the direct and transcriptional regulatory effects of miRNAs on target mRNAs using a dual-luciferase reporter assay.

Results: The miRNA/mRNA PBMC expression profiles of the discovery cohort, of whom eight survived and eight died, revealed a prognostic interactive network involving 38 miRNAs and 313 mRNAs; this was constructed by identifying the target genes of the miRNAs. We validated the expression data in another cohort, of whom 43 survived and 35 died; miR-6840-3p, miR-6861-3p, JADE2, and NR3C2 were of particular interest. The levels of miR-6840-3p and miR-6861-3p were significantly increased in the PBMCs of the patients who died, and thus predicted prognosis (areas under the curve values = 0.665 and 0.700, respectively). The dual-luciferase reporter assay indicated that miR-6840-3p directly targeted JADE2.

Conclusion: We identified a prognostic miRNA-mRNA co-regulatory network in the PBMCs of HBV-ACLF patients. miR-6840-3p-JADE2 is a potential miRNA–mRNA pair contributing to a poor prognosis.”

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.